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龙图腾网获悉天津凯莱英生物科技有限公司申请的专利α-氨基酸酯酰基转移酶突变体及其应用获国家发明授权专利权，本发明授权专利权由国家知识产权局授予，授权公告号为：CN119876085B 。

龙图腾网通过国家知识产权局官网在2025-09-26发布的发明授权授权公告中获悉：该发明授权的专利申请号/专利号为：202510382491.9，技术领域涉及：C12N9/18；该发明授权α-氨基酸酯酰基转移酶突变体及其应用是由洪浩;詹姆斯·盖吉;张娜;焦学成;马玉磊;王召帅;张海彬;安向向;李怡霈;马天娇设计研发完成，并于2025-03-28向国家知识产权局提交的专利申请。

本α-氨基酸酯酰基转移酶突变体及其应用在说明书摘要公布了：本发明提供了一种α‑氨基酸酯酰基转移酶突变体及其应用。该α‑氨基酸酯酰基转移酶突变体包括：（a）具有SEQIDNO：1所示的氨基酸序列的蛋白质；（b）在（a）中的上述氨基酸序列的如下至少一个位点：P158、K80、T208、A302、A175、N85、N605、K346、S225、I34或S348，经过氨基酸突变且具有α‑氨基酸酯酰基转移酶功能的蛋白质；或（c）与（a）或（b）中限定的上述氨基酸序列具有80%以上同源性且具有α‑氨基酸酯酰基转移酶功能的蛋白质。本发明的α‑氨基酸酯酰基转移酶突变体具有底物谱广和催化活性高的优势，能够较好的用于寡肽的合成，成本低且收率高，实现了真正的绿色化学。

本发明授权α-氨基酸酯酰基转移酶突变体及其应用在权利要求书中公布了：1.一种α-氨基酸酯酰基转移酶突变体，其特征在于，所述α-氨基酸酯酰基转移酶突变体为： （a）氨基酸序列为SEQIDNO：1所示的蛋白质；或 （b）在（a）中的所述氨基酸序列发生如下任意一种氨基酸突变的突变体： P158R、K81P、N85Y、V182F、V182S、W185S、W185G、W185L、P73D、K80A、K80S、K80C、K80R、K80G、T208G、T208F、T208S、T208M、T70D、T70A、T70S、T70G、T70P、T70L、P158R+K80A、P158R+K81P、P158R+K81L、P158R+K81G、P158R+K81S、P158R+R204H、P158R+R204V、P158R+S337H、P158R+E353W、P158R+H350E、P158R+R441P、P158R+F355D、P158R+K80R、P158R+T70D、P158R+T70S、P158R+T70L、P158R+T70G、P158R+V182S、P158R+T208F、P158R+K80A+R204A、P158R+K80A+A299E、P158R+K80A+A202S、P158R+K80A+T208A、P158R+K80A+L261F、P158R+K80A+F205M、P158R+K80A+S337H、P158R+K80A+T208G、P158R+K80A+A302S、P158R+K80A+E353W、P158R+K80A+Q200I、P158R+K80A+K104R、P158R+K80A+T70D、P158R+K80A+R441P、P158R+K80A+F355D、P158R+K80A+R204H、P158R+K80A+D334N、P158R+K80A+D334V、P158R+K80A+R204N、P158R+K80A+W185F、P158R+K80A+W185C、P158R+K80A+N85G、P158R+K80A+R204V、P158R+K80A+Y300C、P158R+K80A+F294L、P158R+K80A+T183V、P158R+K80A+L83I、P158R+K80A+L83M、P158R+K80A+Q200I、P158R+K80A+E304M、P158R+N85G+V349T、P158R+N85G+S348G、P158R+N85G+N318V、P158R+N85G+K346P、P158R+N85G+S165A、P158R+N85G+N233R、P158R+N85G+T70S、P158R+N85G+K346R、P158R+N85G+S348A、P158R+N85G+N605P、P158R+N85G+N605F、P158R+N85G+S225T、P158R+N85G+I447V、P158R+N85G+H350L、P158R+N85G+N605A、P158R+N85G+F355A、P158R+N85G+A322S、P158R+K80A+A302S+K81L、P158R+K80A+A302S+R204H、P158R+K80A+T208G+T70D、P158R+K80A+A302S+R204N、P158R+K80A+A302S+Y300C、P158R+K80A+A302S+F294L、P158R+K80A+A302S+T183V、P158R+K80A+A302S+E304M、P158R+K80A+A302S+D334V、P158R+K80A+A302S+K81G、P158R+K80A+T208G+K311S、P158R+K80A+T208G+N605L、P158R+K80A+T208G+S225E、P158R+K80A+T208G+S225N、P158R+K80A+T208G+P535S、P158R+K80A+T208G+N605F、P158R+K80A+T208G+K311R、P158R+K80A+T208G+P535S、P158R+K80A+T208G+Y228A、P158R+K80A+T208G+Q227T、P158R+K80A+T208G+N605L、P158R+K80A+T208G+K311T、P158R+K80A+T208G+A299V、P158R+K80A+T208G+E522D、P158R+K80A+T208G+Q227M、P158R+K80A+T208G+T442S、P158R+K80A+A302S+K81I、P158R+K80A+A302S+L83I、P158R+K80A+T208G+N605P、P158R+K80A+T208G+N605G、P158R+K80A+T208G+K81D、P158R+K80A+T208G+A322I、P158R+K80A+T208G+F209N、P158R+K80A+T208G+A322L、P158R+K80A+A302S+D334N、P158R+K80A+T208G+K81S、P158R+K80A+T208G+L518F、P158R+K80A+A302S+W185C、P158R+K80A+T208G+K81L、P158R+K80A+A302S+T70N、P158R+K80A+A302S+V114L、P158R+K80A+A302S+F198M、P158R+K80A+A302S+A202C、P158R+K80A+A302S+M206H、P158R+K80A+A302S+M206F、P158R+K80A+A302S+Y228M、P158R+K80A+A302S+E353T、P158R+K80A+A302S+E353N、P158R+K80A+A302S+E353S、P158R+K80A+A302S+I497V、P158R+K80A+A302S+P535T、P158R+K80A+A302S+P535S、P158R+K80A+A302S+P535V、P158R+K80A+A302S+N605D、P158R+K80A+A302S+N605L、P158R+K80A+A302S+E439C、P158R+K80A+A302S+K346P、P158R+K80A+A302S+Y69N、P158R+K80A+A302S+T70D、P158R+K80A+A302S+T70G、P158R+K80A+A302S+T70M、P158R+K80A+A302S+K81S、P158R+K80A+A302S+N85G、P158R+K80A+A302S+V114I、P158R+K80A+A302S+A150V、P158R+K80A+A302S+A175V、P158R+K80A+A302S+W185F、P158R+K80A+A302S+A202S、P158R+K80A+A302S+M206S、P158R+K80A+A302S+F209N、P158R+K80A+A302S+Y228A、P158R+K80A+A302S+Y228L、P158R+K80A+A302S+V287T、P158R+K80A+A302S+V289I、P158R+K80A+A302S+V289L、P158R+K80A+A302S+V321A、P158R+K80A+A302S+R332S、P158R+K80A+A302S+T70N、P158R+K80A+A302S+T70S、P158R+K80A+A302S+V114L、P158R+K80A+A302S+F198M、P158R+K80A+A302S+A202C、P158R+K80A+A302S+M206H、P158R+K80A+A302S+M206F、P158R+K80A+A302S+Y228M、P158R+K80A+A302S+E353T、P158R+K80A+A302S+E353N、P158R+K80A+A302S+E353S、P158R+K80A+A302S+I497V、P158R+K80A+A302S+P535T、P158R+K80A+A302S+P535S、P158R+K80A+A302S+P535V、P158R+K80A+A302S+N605D、P158R+K80A+A302S+N605L、P158R+K80A+A302S+E439C、P158R+K80A+A302S+K346P、P158R+K80A+A302S+Y69N、P158R+K80A+A302S+T70D、P158R+K80A+A302S+T70G、P158R+K80A+A302S+T70M、P158R+K80A+A302S+N85G、P158R+K80A+A302S+V114I、P158R+K80A+A302S+A150V、P158R+K80A+A302S+A175V、P158R+K80A+A302S+W185F、P158R+K80A+A302S+A202S、P158R+K80A+A302S+M206S、P158R+K80A+A302S+F209N、P158R+K80A+A302S+E353Y、P158R+K80A+A302S+N605F、P158R+K80A+A302S+N605G、P158R+K80A+A302S+K81D、P158R+K80A+A302S+A322I、P158R+K80A+A302S+F209N、P158R+K80A+A302S+A322L、P158R+K80A+A302S+L518F、P158R+K80A+A302S+Q227T、P158R+K80A+A302S+K311T、P158R+K80A+A302S+A299V、P158R+K80A+A302S+E522D、P158R+K80A+A302S+Q227M、P158R+K80A+A302S+T442S、P158R+N85G+N605P+K346N、P158R+N85G+N605P+F198M、P158R+N85G+N605P+H350L、P158R+N85G+N605P+K80K、P158R+N85G+N605P+S225M、P158R+N85G+N605P+A302T、P158R+N85G+N605P+T549Y、P158R+N85G+N605P+K81T、P158R+N85G+N605P+K81R、P158R+N85G+N605P+K81E、P158R+N85G+N605P+K81S、P158R+N85G+N605P+K215T、P158R+N85G+N605P+F198W、P158R+N85G+N605P+A299T、P158R+K80A+A302S+N605F+Q227I、P158R+K80A+A302S+N605F+Q227V、P158R+K80A+A302S+N605F+I34T、P158R+N85G+N605P+K346N+S225R、P158R+N85G+N605P+K346N+S225A、P158R+N85G+N605P+K346N+S225T、P158R+K80A+A302S+N605F+S225E、P158R+K80A+A302S+N605F+K81M、P158R+K80A+A302S+N605F+N440T、P158R+K80A+A302S+N605F+T506G、P158R+K80A+A302S+N605F+H350Y、P158R+K80A+A302S+N605F+K81S、P158R+K80A+A302S+N605F+H350T、P158R+K80A+A302S+N605F+T506G、P158R+N85G+N605P+K346N+F198M、P158R+N85G+N605P+K346N+H350L、P158R+N85G+N605P+K346N+S225M、P158R+N85G+N605P+K346N+A302T、P158R+N85G+N605P+K346N+T549Y、P158R+N85G+N605P+K346N+K81T、P158R+N85G+N605P+K346N+K81R、P158R+N85G+N605P+K346N+F198W、P158R+N85G+N605P+K346N+K81E、P158R+N85G+N605P+K346N+K215T、P158R+N85G+N605P+K346N+K81S、P158R+N85G+N605P+K346N+A299T、P158R+N85G+N605P+K346N+I187L、P158R+N85G+N605P+K346N+S225T+I34K、P158R+N85G+N605P+K346N+S225T+I34A、P158R+N85G+N605P+K346N+S225T+I34P、P158R+N85G+N605P+K346N+S225T+I34R、P158R+N85G+N605P+K346N+S225T+I34H、P158R+N85G+N605P+K346N+S225T+I34S、P158R+N85G+N605P+K346N+S225T+S348G、P158R+N85G+N605P+K346N+S225T+I34K+S348G、P158R+N85G+N605P+K346N+S225T+I34K+S348A、P158R+N85G+N605P+K346N+S225T+I34K+S348P、P158R+N85G+N605P+K346N+S225T+I34K+S348K、P158R+N85G+N605P+K346N+S225T+I34K+S348N、P158R+N85G+N605P+K346N+S225T+I34K+S348M、P158R+N85G+N605P+K346N+S225T+I34K+S348C或P158R+N85G+N605P+K346N+S225T+I34K+S348V。

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