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龙图腾网获悉哈佛大学校长及研究员协会申请的专利RNA-引导的人类基因组工程化获国家发明授权专利权，本发明授权专利权由国家知识产权局授予，授权公告号为：CN105121641B 。

龙图腾网通过国家知识产权局官网在2025-11-11发布的发明授权授权公告中获悉：该发明授权的专利申请号/专利号为：201380073208.X，技术领域涉及：C12N15/00；该发明授权RNA-引导的人类基因组工程化是由乔治·M·丘奇;普拉尚特·马利;杨璐菡设计研发完成，并于2013-12-16向国家知识产权局提交的专利申请。

本RNA-引导的人类基因组工程化在说明书摘要公布了：提供了一种改变真核细胞的方法，包括用编码与真核细胞的基因组DNA互补的RNA的核酸转染真核细胞，用编码与RNA相互作用并且以位点特异性方式切割基因组DNA的酶的核酸转染该真核细胞，其中该细胞表达该RNA和该酶，该RNA结合于互补的基因组DNA并且该酶以位点特异性方式切割该基因组DNA。

本发明授权RNA-引导的人类基因组工程化在权利要求书中公布了：1.向导RNA序列和与所述向导RNA序列相互作用的Cas9蛋白用于制备用于改变真核细胞的产品的用途，所述向导RNA序列包含间隔子序列、crRNA序列和tracrRNA序列，所述间隔子序列与真核细胞内靶核酸序列互补，所述改变的方法包括 向所述真核细胞提供所述包含与靶核酸序列互补的间隔子序列的向导RNA序列，其中所述向导RNA序列结合所述靶核酸序列，并 向所述真核细胞提供与所述向导RNA序列相互作用的所述Cas9蛋白； 所述Cas9蛋白的编码序列是： gccaccatggacaagaagtactccattgggctcgatatcggcacaaacagcgtcggctgg60 gccgtcattacggacgagtacaaggtgccgagcaaaaaattcaaagttctgggcaatacc120 gatcgccacagcataaagaagaacctcattggcgccctcctgttcgactccggggagacg180 gccgaagccacgcggctcaaaagaacagcacggcgcagatatacccgcagaaagaatcgg240 atctgctacctgcaggagatctttagtaatgagatggctaaggtggatgactctttcttc300 cataggctggaggagtcctttttggtggaggaggataaaaagcacgagcgccacccaatc360 tttggcaatatcgtggacgaggtggcgtaccatgaaaagtacccaaccatatatcatctg420 aggaagaagcttgtagacagtactgataaggctgacttgcggttgatctatctcgcgctg480 gcgcatatgatcaaatttcggggacacttcctcatcgagggggacctgaacccagacaac540 agcgatgtcgacaaactctttatccaactggttcagacttacaatcagcttttcgaagag600 aacccgatcaacgcatccggagttgacgccaaagcaatcctgagcgctaggctgtccaaa660 tcccggcggctcgaaaacctcatcgcacagctccctggggagaagaagaacggcctgttt720 ggtaatcttatcgccctgtcactcgggctgacccccaactttaaatctaacttcgacctg780 gccgaagatgccaagcttcaactgagcaaagacacctacgatgatgatctcgacaatctg840 ctggcccagatcggcgaccagtacgcagacctttttttggcggcaaagaacctgtcagac900 gccattctgctgagtgatattctgcgagtgaacacggagatcaccaaagctccgctgagc960 gctagtatgatcaagcgctatgatgagcaccaccaagacttgactttgctgaaggccctt1020 gtcagacagcaactgcctgagaagtacaaggaaattttcttcgatcagtctaaaaatggc1080 tacgccggatacattgacggcggagcaagccaggaggaattttacaaatttattaagccc1140 atcttggaaaaaatggacggcaccgaggagctgctggtaaagcttaacagagaagatctg1200 ttgcgcaaacagcgcactttcgacaatggaagcatcccccaccagattcacctgggcgaa1260 ctgcacgctatcctcaggcggcaagaggatttctacccctttttgaaagataacagggaa1320 aagattgagaaaatcctcacatttcggataccctactatgtaggccccctcgcccgggga1380 aattccagattcgcgtggatgactcgcaaatcagaagagaccatcactccctggaacttc1440 gaggaagtcgtggataagggggcctctgcccagtccttcatcgaaaggatgactaacttt1500 gataaaaatctgcctaacgaaaaggtgcttcctaaacactctctgctgtacgagtacttc1560 acagtttataacgagctcaccaaggtcaaatacgtcacagaagggatgagaaagccagca1620 ttcctgtctggagagcagaagaaagctatcgtggacctcctcttcaagacgaaccggaaa1680 gttaccgtgaaacagctcaaagaagactatttcaaaaagattgaatgtttcgactctgtt1740 gaaatcagcggagtggaggatcgcttcaacgcatccctgggaacgtatcacgatctcctg1800 aaaatcattaaagacaaggacttcctggacaatgaggagaacgaggacattcttgaggac1860 attgtcctcacccttacgttgtttgaagatagggagatgattgaagaacgcttgaaaact1920 tacgctcatctcttcgacgacaaagtcatgaaacagctcaagaggcgccgatatacagga1980 tgggggcggctgtcaagaaaactgatcaatgggatccgagacaagcagagtggaaagaca2040 atcctggattttcttaagtccgatggatttgccaaccggaacttcatgcagttgatccat2100 gatgactctctcacctttaaggaggacatccagaaagcacaagtttctggccagggggac2160 agtcttcacgagcacatcgctaatcttgcaggtagcccagctatcaaaaagggaatactg2220 cagaccgttaaggtcgtggatgaactcgtcaaagtaatgggaaggcataagcccgagaat2280 atcgttatcgagatggcccgagagaaccaaactacccagaagggacagaagaacagtagg2340 gaaaggatgaagaggattgaagagggtataaaagaactggggtcccaaatccttaaggaa2400 cacccagttgaaaacacccagcttcagaatgagaagctctacctgtactacctgcagaac2460 ggcagggacatgtacgtggatcaggaactggacatcaatcggctctccgactacgacgtg2520 gatcatatcgtgccccagtcttttctcaaagatgattctattgataataaagtgttgaca2580 agatccgataaaaatagagggaagagtgataacgtcccctcagaagaagttgtcaagaaa2640 atgaaaaattattggcggcagctgctgaacgccaaactgatcacacaacggaagttcgat2700 aatctgactaaggctgaacgaggtggcctgtctgagttggataaagccggcttcatcaaa2760 aggcagcttgttgagacacgccagatcaccaagcacgtggcccaaattctcgattcacgc2820 atgaacaccaagtacgatgaaaatgacaaactgattcgagaggtgaaagttattactctg2880 aagtctaagctggtctcagatttcagaaaggactttcagttttataaggtgagagagatc2940 aacaattaccaccatgcgcatgatgcctacctgaatgcagtggtaggcactgcacttatc3000 aaaaaatatcccaagcttgaatctgaatttgtttacggagactataaagtgtacgatgtt3060 aggaaaatgatcgcaaagtctgagcaggaaataggcaaggccaccgctaagtacttcttt3120 tacagcaatattatgaattttttcaagaccgagattacactggccaatggagagattcgg3180 aagcgaccacttatcgaaacaaacggagaaacaggagaaatcgtgtgggacaagggtagg3240 gatttcgcgacagtccggaaggtcctgtccatgccgcaggtgaacatcgttaaaaagacc3300 gaagtacagaccggaggcttctccaaggaaagtatcctcccgaaaaggaacagcgacaag3360 ctgatcgcacgcaaaaaagattgggaccccaagaaatacggcggattcgattctcctaca3420 gtcgcttacagtgtactggttgtggccaaagtggagaaagggaagtctaaaaaactcaaa3480 agcgtcaaggaactgctgggcatcacaatcatggagcgatcaagcttcgaaaaaaacccc3540 atcgactttctcgaggcgaaaggatataaagaggtcaaaaaagacctcatcattaagctt3600 cccaagtactctctctttgagcttgaaaacggccggaaacgaatgctcgctagtgcgggc3660 gagctgcagaaaggtaacgagctggcactgccctctaaatacgttaatttcttgtatctg3720 gccagccactatgaaaagctcaaagggtctcccgaagataatgagcagaagcagctgttc3780 gtggaacaacacaaacactaccttgatgagatcatcgagcaaataagcgaattctccaaa3840 agagtgatcctcgccgacgctaacctcgataaggtgctttctgcttacaataagcacagg3900 gataagcccatcagggagcaggcagaaaacattatccacttgtttactctgaccaacttg3960 ggcgcgcctgcagccttcaagtacttcgacaccaccatagacagaaagcggtacacctct4020 acaaaggaggtcctggacgccacactgattcatcagtcaattacggggctctatgaaaca4080 agaatcgacctctctcagctcggtggagacagcagggctgaccccaagaagaagaggaag4140 gtgtga4146。

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