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龙图腾网获悉中国农业科学院兰州兽医研究所(中国动物卫生与流行病学中心兰州分中心)申请的专利一种可自我切割并表达多个病毒结构蛋白的PDCoV病毒mRNA疫苗及其制备方法获国家发明授权专利权，本发明授权专利权由国家知识产权局授予，授权公告号为：CN120514838B 。

龙图腾网通过国家知识产权局官网在2025-11-21发布的发明授权授权公告中获悉：该发明授权的专利申请号/专利号为：202510654745.8，技术领域涉及：A61K39/295；该发明授权一种可自我切割并表达多个病毒结构蛋白的PDCoV病毒mRNA疫苗及其制备方法是由刘新生;张莉萍;潘丽;于瑞明;周鹏;张中旺;白英杰;王永录;郭慧琛设计研发完成，并于2025-05-21向国家知识产权局提交的专利申请。

本一种可自我切割并表达多个病毒结构蛋白的PDCoV病毒mRNA疫苗及其制备方法在说明书摘要公布了：本发明提供了一种可自我切割并表达多个病毒结构蛋白的PDCoV病毒mRNA疫苗及其制备方法，所述疫苗包括表达PDCoV病毒S、M、N蛋白的mRNA，以及包封所述mRNA的LNP，记为SMN‑mRNA‑LNP。本发明首次提出基于S、M、N联合的PDCoVmRNA疫苗策略，将PDCoVS、M和N三种结构蛋白利用自剪切肽P2A连接，并将S蛋白进行双脯氨酸突变，使单个mRNA能够表达多种PDCoV抗原，并利用S蛋白的中和抗体诱导能力、M蛋白的免疫调节功能及N蛋白的细胞免疫激活特性，构建多层次防御体系。通过对该疫苗在小鼠、哺乳仔猪和怀孕母猪中免疫原性、抗体水平及攻毒保护效果的评估，为开发广谱、高效的PDCoV疫苗提供新思路，并为冠状病毒多抗原mRNA疫苗的研发提供实践依据。

本发明授权一种可自我切割并表达多个病毒结构蛋白的PDCoV病毒mRNA疫苗及其制备方法在权利要求书中公布了：1.一种可自我切割并表达多个病毒结构蛋白的PDCoV病毒mRNA疫苗，其特征在于，包括同时表达PDCoV病毒S、M、N蛋白的mRNA，以及包封所述mRNA的LNP，记为SMN-mRNA-LNP，所述mRNA的核苷酸序列如下： 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如需购买、转让、实施、许可或投资类似专利技术，可联系本专利的申请人或专利权人中国农业科学院兰州兽医研究所(中国动物卫生与流行病学中心兰州分中心)，其通讯地址为：730046 甘肃省兰州市城关区盐场堡徐家坪1号；或者联系龙图腾网官方客服，联系龙图腾网可拨打电话0551-65771310或微信搜索“龙图腾网”。

以上内容由龙图腾AI智能生成。